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Concomitant utilization of benzodiazepines and opioids may lead to profound sedation, respiratory melancholy, coma, and Loss of life. Reserve concomitant prescribing of these medicines for individuals for whom substitute therapy selections are inadequate.
The use of alprazolam with opioid medicines has led to serious Unwanted side effects including slowed and problem breathing and Demise.
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Compounds that are inhibitors or inducers of CYP3A might be expected to increase or minimize plasma alprazolam concentrations, respectively.
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